Platelet-rich plasma: from laboratory to the clinic

PRP preparations contain high concentrations of platelets that, once activated, undergo degranulation to release growth factors with healing properties. Due to its autogenous origin, easy preparation, inexpensiveness, and excellent safety profile, the use of PRP technologies has opened a gait to the treatment of soft-tissue injuries. PRP has been increasingly used in sports-related injuries for therapeutic appli- cations. Since sports medicine patients desire earlier return to training and competition, PRP may have certain applications that will speed recovery in cases of tendon, ligament, muscle, and cartilage disorders. There is still an ongoing debate about the positive clinical and experi- mental outcomes. Despite the lack of hard evidence through randomized clinical trials, clinical observations and opinions suggest that pain relief and return to function occur more rapidly than expected for some healing ortho- pedic problems after the use of PRP. This chapter will focus on the laboratory studies about the effects of PRP on the most common sports- related injury areas and thus the brief review of the clinical studies.

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